A new supplement called Oxyfil containing plant extracts and citrulline reduced inflammatory markers in prostate tissue and improved urinary flow and symptoms in 59 men with enlarged prostates when used alongside standard medications, according to a 2026 clinical study. Lab tests showed the supplement contains 25 active plant compounds that protect prostate cells from inflammation and oxidative stress.
Researchers tested a new dietary supplement called Oxyfil that combines plant extracts and an amino acid to help with lower urinary tract symptoms in men with enlarged prostates. In lab tests, the supplement reduced inflammation and oxidative stress in prostate tissue. When 59 men with moderate to severe urinary symptoms took Oxyfil, either alone or with standard medications, they experienced improvements in urinary flow and symptom relief. The study suggests this plant-based formula may work alongside conventional treatments to provide additional benefits for men struggling with prostate-related urinary problems.
Key Statistics
A 2026 clinical study of 59 men found that Oxyfil, a supplement combining plant extracts and citrulline, improved urinary flow rate and symptom scores when used with standard prostate medications.
Laboratory analysis identified 25 phenolic compounds in the Oxyfil formulation that reduced inflammatory markers including COX-2, TNFα, and IL-6 in prostate tissue exposed to bacterial toxins.
In the 2026 study, patients receiving Oxyfil combined with alpha-blockers, PDE5 inhibitors, or 5-alpha reductase inhibitors showed measurable improvements in both urinary flow and symptom severity scores.
The Quick Take
- What they studied: Whether a new supplement containing plant extracts and an amino acid could reduce inflammation in the prostate and improve urinary symptoms in men with enlarged prostates.
- Who participated: 59 men aged 50-75 years with moderate to severe lower urinary tract symptoms and mild erectile dysfunction. Some took the supplement alone, while others combined it with standard prostate medications.
- Key finding: The supplement reduced inflammatory markers in lab-grown prostate tissue and improved urinary flow and symptom scores in patients when used alongside standard treatments.
- What it means for you: If you have an enlarged prostate with urinary symptoms, this supplement may offer additional relief when combined with your doctor’s recommended treatment. However, always consult your healthcare provider before starting any new supplement, as this study is preliminary and more research is needed.
The Research Details
The research had two parts. First, scientists tested the supplement in a laboratory using mouse prostate tissue exposed to bacterial toxins that trigger inflammation. They measured whether the supplement could reduce inflammatory markers and oxidative stress, cellular damage caused by harmful molecules. Second, they conducted a clinical trial with 59 real patients who had enlarged prostates and urinary problems. Patients received either the supplement alone or combined with standard medications like alpha-blockers, PDE5 inhibitors, or 5-alpha reductase inhibitors. Researchers tracked improvements in urinary flow rate and symptom severity using standardized questionnaires.
This two-part approach is valuable because lab studies show how a treatment works at the cellular level, while patient studies show whether those benefits actually help real people. By combining both types of evidence, researchers can better understand if the supplement’s anti-inflammatory effects translate into meaningful symptom relief. This approach also helps identify which patients might benefit most from the treatment.
Strengths: The study included chemical analysis identifying 25 active compounds in the supplement, providing transparency about what’s actually in the product. The clinical trial involved multiple medical centers, increasing the reliability of findings. Limitations: The clinical trial was not randomized (patients weren’t randomly assigned to groups), which can introduce bias. The sample size of 59 patients is relatively small. The study was retrospective, meaning researchers looked back at existing medical records rather than following patients prospectively. These limitations mean results should be considered preliminary and require confirmation in larger, more rigorous trials.
What the Results Show
In laboratory tests, Oxyfil successfully reduced the production of inflammatory molecules in prostate tissue exposed to bacterial toxins. Specifically, the supplement blunted the upregulation of six key inflammatory and oxidative stress markers: COX-2, i-NOS, TNFα, IL-6, VEGFA, and HIF1α. These are molecules that drive inflammation and cellular damage in prostate disease. The supplement contains 25 phenolic compounds, natural plant chemicals with anti-inflammatory and antioxidant properties, which likely explain these protective effects. In the clinical trial, patients who received Oxyfil showed measurable improvements in urinary flow rate (measured by uroflowmetry) and symptom scores on the International Prostate Symptom Scale (IPSS). These improvements were observed whether patients took the supplement alone or combined it with standard prostate medications.
The study found that Oxyfil was well-tolerated across all patient groups, with no serious safety concerns reported. The supplement appeared effective when combined with different classes of standard prostate medications, suggesting it may work synergistically with conventional treatments. Patients taking Oxyfil plus alpha-blockers, PDE5 inhibitors, or 5-alpha reductase inhibitors all showed symptom improvement, indicating the supplement doesn’t interfere with these medications and may enhance their benefits.
Individual plant ingredients in Oxyfil have been studied separately. Saw palmetto and other plant extracts have shown modest benefits for prostate symptoms in previous research. This study is notable because it combines multiple plant extracts with citrulline (an amino acid that improves blood flow) into a single formulation. The combination approach may provide additive benefits beyond what each ingredient alone could achieve. However, this is one of the first studies examining this specific combination, so direct comparisons to prior research are limited.
The clinical trial was retrospective and non-randomized, meaning researchers couldn’t control for all variables that might affect outcomes. The sample size of 59 patients is relatively small for drawing firm conclusions. The study lacked a true control group (patients who received placebo or no treatment), making it difficult to determine how much improvement came from Oxyfil versus standard medications or natural disease progression. The study didn’t measure long-term outcomes beyond the treatment period. Additionally, the study was conducted at specific medical centers, which may limit how well results apply to other populations.
The Bottom Line
According to Gram Research analysis, this supplement may be worth discussing with your urologist if you have an enlarged prostate with moderate to severe urinary symptoms, especially if standard treatments alone aren’t providing adequate relief. The evidence suggests combining Oxyfil with standard medications may be more effective than either approach alone. However, confidence in these recommendations is moderate because the clinical evidence is preliminary. Always consult your healthcare provider before starting any supplement, particularly if you take other medications.
Men aged 50-75 with enlarged prostates and moderate to severe lower urinary tract symptoms are the primary candidates for this supplement. Men with mild erectile dysfunction may also benefit. You should NOT use this supplement if you have bladder-neck sclerosis, urethral stricture, or hormone-related erectile dysfunction without medical supervision. Pregnant women and children should not use this product. Anyone with allergies to any of the plant ingredients should avoid it.
Based on the study data, patients showed measurable improvements in urinary flow and symptom scores during the treatment period, though the exact timeline for noticing benefits isn’t specified in this research. Most prostate supplements typically require 4-12 weeks of consistent use before noticeable improvements occur. Individual results vary significantly, and some men may see benefits sooner while others require longer treatment periods.
Frequently Asked Questions
Can this supplement help with enlarged prostate symptoms?
Research shows Oxyfil may improve urinary flow and symptom scores in men with enlarged prostates, particularly when combined with standard medications. A 2026 study of 59 men found measurable improvements in urinary function and symptom severity. Consult your doctor before starting.
What are the main ingredients in Oxyfil and what do they do?
Oxyfil contains extracts from four plants, Epilobium angustifolium, Ptychopetalum olacoides, Ginkgo biloba, and Equisetum arvense, plus citrulline. These ingredients contain 25 active compounds with anti-inflammatory and antioxidant properties that protect prostate cells from damage and reduce inflammation.
Is it safe to take this supplement with prostate medications?
The 2026 study found Oxyfil was well-tolerated when combined with alpha-blockers, PDE5 inhibitors, and 5-alpha reductase inhibitors, with no serious safety concerns reported. However, always inform your doctor about any supplements you’re taking to check for potential interactions.
How long does it take to see results from this supplement?
The study doesn’t specify an exact timeline, but most prostate supplements typically require 4-12 weeks of consistent daily use before noticeable improvements appear. Individual results vary, and some men may see benefits sooner while others need longer treatment periods.
Who should not take this supplement?
Avoid Oxyfil if you have bladder-neck sclerosis, urethral stricture, hormone-related erectile dysfunction, or allergies to any plant ingredients. Pregnant women and children should not use this product. Always consult your healthcare provider before starting any new supplement.
Want to Apply This Research?
- Track your urinary stream strength and frequency daily using a simple 1-10 scale. Note the time of day, number of nighttime bathroom visits, and any changes in urinary urgency. This creates a baseline to measure whether the supplement is working for you over weeks and months.
- Set a daily reminder to take your supplement at the same time each day, ideally with food. Log your dose in the app along with any symptoms you notice that day. This consistency helps ensure you’re getting the full benefit and makes it easier to spot patterns in your symptoms.
- Use the app to track your International Prostate Symptom Score (IPSS) monthly by answering seven simple questions about urinary symptoms. Compare your scores month-to-month to see if the supplement is providing real improvement. Share these tracked results with your doctor at regular check-ups to guide treatment decisions.
This article summarizes research findings and is not medical advice. Oxyfil is a dietary supplement, not an FDA-approved medication. The clinical evidence presented is preliminary, based on a small, non-randomized study. Results may vary significantly between individuals. Do not use this supplement to replace standard medical treatment for prostate conditions without consulting your healthcare provider. If you have prostate symptoms, bladder problems, or are taking other medications, discuss this supplement with your doctor before starting. Pregnant women, nursing mothers, and children should not use this product. Discontinue use and seek medical attention if you experience adverse effects.
This research translation is published by Gram Research, the science division of Gram, an AI-powered nutrition tracking app.
